Motif ID: RXRA_VDR{dimer}.p2

Z-value: 0.684


Transcription factors associated with RXRA_VDR{dimer}.p2:

Gene SymbolEntrez IDGene Name
VDR 7421 vitamin D (1,25- dihydroxyvitamin D3) receptor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
VDRchr12_-_46585032-0.702.4e-03Click!


Activity profile for motif RXRA_VDR{dimer}.p2.

activity profile for motif RXRA_VDR{dimer}.p2


Sorted Z-values histogram for motif RXRA_VDR{dimer}.p2

Sorted Z-values for motif RXRA_VDR{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRA_VDR{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_94117483 1.089 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr7_+_94374862 1.044 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr10_+_102722275 1.009 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr1_+_99884018 0.812 NM_017734
PALMD
palmdelphin
chr1_+_199259664 0.728


chr17_-_61655915 0.708 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr19_-_7244876 0.629 NM_000208
NM_001079817
INSR

insulin receptor

chr6_-_132314004 0.624 NM_001901
CTGF
connective tissue growth factor
chr11_+_64620276 0.576 C11orf2
chromosome 11 open reading frame 2
chr11_+_64620287 0.571 C11orf2
chromosome 11 open reading frame 2
chr14_+_94117511 0.548 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr11_+_64620183 0.541 NM_013265
C11orf2
chromosome 11 open reading frame 2
chr16_+_18986459 0.538 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr17_-_31831093 0.511 NM_001123392
NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3H
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3H
TBC1 domain family, member 3F
chr17_+_18320822 0.496 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr17_-_33602374 0.493 NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr17_-_33552166 0.486 NM_001123391
NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr17_-_31528027 0.429 NM_001001417
TBC1D3B
TBC1D3C
TBC1D3G
TBC1D3F
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3F
chr21_-_46399900 0.418 NM_006657
NM_206965
FTCD

formiminotransferase cyclodeaminase

chr17_-_31616071 0.418 NM_001001418
NM_032258
TBC1D3B
TBC1D3C
TBC1D3G
TBC1D3F
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3F
chr17_-_7023378 0.412 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chrX_+_153423652 0.408 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr2_+_20510312 0.369 NM_004040
RHOB
ras homolog gene family, member B
chr22_+_48966394 0.358 TRABD
TraB domain containing
chr21_+_45649429 0.357 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr13_-_74953873 0.345 NM_014832
TBC1D4
TBC1 domain family, member 4
chr16_+_18986417 0.340 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr16_+_18986721 0.336 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chrX_+_46825179 0.335 RGN
regucalcin (senescence marker protein-30)
chr17_+_77528699 0.329 NM_024083
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr5_-_32210084 0.316 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr17_-_20311411 0.313 NM_001042685
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr3_-_49117169 0.305 NM_005051
QARS
glutaminyl-tRNA synthetase
chr18_-_6404900 0.304 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr17_-_59451662 0.288 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr22_+_48966480 0.286 NM_025204
TRABD
TraB domain containing
chr17_+_77528782 0.277 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr19_-_1601246 0.274 NM_001136139
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
chr10_+_80569464 0.271 ZMIZ1
zinc finger, MIZ-type containing 1
chr21_-_45165249 0.270 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr5_-_32210154 0.270 NM_022130
GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr5_-_32210142 0.265 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr22_+_16973556 0.263 TUBA8
tubulin, alpha 8
chr5_-_32210112 0.262 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr14_+_100262943 0.253 NM_003836
DLK1
delta-like 1 homolog (Drosophila)
chr19_+_50100843 0.250 NM_000041
APOE
apolipoprotein E
chr19_-_9592883 0.249 NM_152289
ZNF561
zinc finger protein 561
chr11_+_36572615 0.246 NM_138787
C11orf74
chromosome 11 open reading frame 74
chr5_-_32209999 0.238 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr7_+_128365226 0.237 NM_001098629
NM_001098630
IRF5

interferon regulatory factor 5

chr22_+_16973399 0.235 NM_001193414
NM_018943
TUBA8

tubulin, alpha 8

chr14_-_34943574 0.230 NM_020529
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr2_-_39517795 0.227 MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr1_+_181259317 0.227


chr10_+_30763056 0.226 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr8_-_93184629 0.220 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr11_+_7491789 0.218 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr21_-_45165204 0.211 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr19_-_48700824 0.210 NM_198850
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr2_+_230495439 0.210 NM_174899
FBXO36
F-box protein 36
chr21_+_45649719 0.209


chr22_+_21464980 0.205


chr6_-_7855125 0.204 NM_001145549
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr2_+_108271526 0.200 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2

chr19_+_10652025 0.198


chr2_+_46623396 0.196 RHOQ
ras homolog gene family, member Q
chr10_-_101831579 0.193 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr10_+_111757867 0.191 ADD3
adducin 3 (gamma)
chr14_-_34661387 0.190 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr1_+_110329224 0.189 AHCYL1
adenosylhomocysteinase-like 1
chr16_+_55950195 0.186 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr19_-_54267932 0.183 NM_031886
KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr17_-_74289901 0.182 NM_004762
NM_017456
CYTH1

cytohesin 1

chr14_-_33489708 0.181 NM_022073
EGLN3
egl nine homolog 3 (C. elegans)
chr1_+_202031373 0.178 NM_014827
ZC3H11A
zinc finger CCCH-type containing 11A
chr20_+_337346 0.178 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr7_-_94863558 0.178 NM_000940
PON3
paraoxonase 3
chr1_+_202031425 0.177 ZC3H11A
zinc finger CCCH-type containing 11A
chr16_+_14634324 0.173 BFAR
bifunctional apoptosis regulator
chr11_+_66034652 0.166 NM_024649
BBS1
Bardet-Biedl syndrome 1
chr22_+_21543671 0.164 IGLV4-3
immunoglobulin lambda variable 4-3
chr20_+_46971618 0.163 NM_006420
ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr6_+_31538934 0.161 NM_006674
HCP5
HLA complex P5
chr17_-_8006979 0.161 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr1_-_181826292 0.160 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr7_+_128365482 0.158 NM_032643
IRF5
interferon regulatory factor 5
chr14_+_57834962 0.152 NM_002892
NM_023000
NM_023001
ARID4A


AT rich interactive domain 4A (RBP1-like)


chr4_-_2727548 0.148 NM_001161527
TNIP2
TNFAIP3 interacting protein 2
chr21_+_39099624 0.145 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr2_-_203444468 0.144 NM_138468
ICA1L
islet cell autoantigen 1,69kDa-like
chr12_+_68459015 0.144 NM_001024647
RAB3IP
RAB3A interacting protein (rabin3)
chr15_+_72861767 0.140 CSK
c-src tyrosine kinase
chr14_-_93926679 0.140 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr9_-_5823072 0.140 NM_024896
ERMP1
endoplasmic reticulum metallopeptidase 1
chr1_+_202031445 0.139 ZC3H11A
zinc finger CCCH-type containing 11A
chr18_-_31178415 0.136 NM_006965
ZNF24
zinc finger protein 24
chr6_+_35335456 0.133 NM_003427
ZNF76
zinc finger protein 76
chr1_+_110328955 0.132 AHCYL1
adenosylhomocysteinase-like 1
chr19_+_40223249 0.130 NM_002151
NM_182983
HPN

hepsin

chr16_+_14634168 0.129 NM_016561
BFAR
bifunctional apoptosis regulator
chr19_+_54962075 0.126 AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr9_+_20648307 0.125 NM_017794
KIAA1797
KIAA1797
chr19_-_4510713 0.124 SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr20_+_3749164 0.123 NM_018347
C20orf29
chromosome 20 open reading frame 29
chr16_-_88295595 0.123 NM_152339
SPATA2L
spermatogenesis associated 2-like
chr12_-_6450015 0.120 NM_014231
NM_016830
NM_199245
VAMP1


vesicle-associated membrane protein 1 (synaptobrevin 1)


chr19_-_47451119 0.119 NM_006494
ERF
Ets2 repressor factor
chr12_+_55896844 0.119 NM_007224
NXPH4
neurexophilin 4
chr15_+_89229275 0.117 NM_001143783
NM_001143784
FES

feline sarcoma oncogene

chr1_-_45924770 0.117 NM_021639
GPBP1L1
GC-rich promoter binding protein 1-like 1
chr11_+_63754328 0.117 NM_005528
DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4
chr10_+_35524835 0.117 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr1_+_227473458 0.115 NM_004578
RAB4A
RAB4A, member RAS oncogene family
chr11_+_59979857 0.115 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr11_+_17254854 0.115 NM_005013
NUCB2
nucleobindin 2
chrX_-_130251068 0.111 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr9_-_5822840 0.111 ERMP1
endoplasmic reticulum metallopeptidase 1
chr17_+_69974375 0.108 CD300A
CD300a molecule
chr3_+_12367993 0.108 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr21_+_39099717 0.107 NM_005239
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr14_-_34661156 0.106 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr4_+_1872150 0.106 NM_133334
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr14_-_34660902 0.103 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr15_-_41000100 0.103 NM_173500
TTBK2
tau tubulin kinase 2
chr7_-_38637475 0.102 AMPH
amphiphysin
chr1_+_149309703 0.102 NM_144618
GABPB2
GA binding protein transcription factor, beta subunit 2
chr19_-_47450991 0.101 ERF
Ets2 repressor factor
chr3_-_150952944 0.101 NM_016094
COMMD2
COMM domain containing 2
chr16_+_15950707 0.101 NM_004996
NM_019862
NM_019898
NM_019899
NM_019900
ABCC1




ATP-binding cassette, sub-family C (CFTR/MRP), member 1




chr6_-_8009560 0.101 MUTED-TXNDC5
MUTED
MUTED-TXNDC5 read-through transcript
muted homolog (mouse)
chr3_+_52504410 0.100 STAB1
stabilin 1
chr22_+_45071301 0.099 NM_016426
GTSE1
G-2 and S-phase expressed 1
chr7_-_120285364 0.098 NM_012338
TSPAN12
tetraspanin 12
chrX_-_39921525 0.096 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr12_-_6668085 0.094 NM_001039916
ZNF384
zinc finger protein 384
chr3_-_197643693 0.093 UBXN7
UBX domain protein 7
chr14_+_57835028 0.092 ARID4A
AT rich interactive domain 4A (RBP1-like)
chr4_-_2727816 0.092 NM_024309
TNIP2
TNFAIP3 interacting protein 2
chr18_-_31178379 0.089 ZNF24
zinc finger protein 24
chr11_+_124115051 0.088 NRGN
neurogranin (protein kinase C substrate, RC3)
chr22_+_44084430 0.084 NM_017911
FAM118A
family with sequence similarity 118, member A
chr16_-_31013626 0.083 NM_024006
NM_206824
VKORC1

vitamin K epoxide reductase complex, subunit 1

chr3_-_54937001 0.083 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chr3_-_197643669 0.082 UBXN7
UBX domain protein 7
chr11_-_65841077 0.082 NM_020404
CD248
CD248 molecule, endosialin
chr19_-_12305435 0.081 NM_145276
ZNF563
zinc finger protein 563
chr19_+_60878381 0.080 EPN1
epsin 1
chr6_-_79844606 0.078 PHIP
pleckstrin homology domain interacting protein
chr16_-_3707450 0.078 NM_016292
TRAP1
TNF receptor-associated protein 1
chr1_-_44912704 0.077 TMEM53
transmembrane protein 53
chr3_+_153469421 0.077 MBNL1
muscleblind-like (Drosophila)
chr15_+_67239853 0.076 NM_015554
GLCE
glucuronic acid epimerase
chr4_+_2764510 0.076 NM_001122681
SH3BP2
SH3-domain binding protein 2
chr3_-_197643701 0.073 NM_015562
UBXN7
UBX domain protein 7
chr16_-_31013550 0.073 VKORC1
vitamin K epoxide reductase complex, subunit 1
chr1_-_39929654 0.071 NM_016257
HPCAL4
hippocalcin like 4
chr12_+_112143658 0.071 TPCN1
two pore segment channel 1
chr17_+_7063873 0.071 NM_000018
NM_001033859
ACADVL

acyl-CoA dehydrogenase, very long chain

chr16_+_11978002 0.071 NM_032167
RUNDC2A
RUN domain containing 2A
chr15_+_57691272 0.070 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr12_+_112143670 0.070 TPCN1
two pore segment channel 1
chr20_+_37024383 0.069 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr1_+_224803123 0.069 NM_001003665
C1orf95
chromosome 1 open reading frame 95
chr9_+_115396020 0.069 NM_144489
RGS3
regulator of G-protein signaling 3
chr16_-_31013594 0.069 VKORC1
vitamin K epoxide reductase complex, subunit 1
chr7_+_39956633 0.069 CDK13
cyclin-dependent kinase 13
chr5_-_179166230 0.069 MGAT4B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
chr11_-_73700257 0.068 NM_182904
P4HA3
prolyl 4-hydroxylase, alpha polypeptide III
chr2_-_118488189 0.067 NM_019044
CCDC93
coiled-coil domain containing 93
chr16_+_1974182 0.066 GFER
growth factor, augmenter of liver regeneration
chr3_+_52504391 0.066 NM_015136
STAB1
stabilin 1
chr7_+_39956480 0.066 NM_003718
NM_031267
CDK13

cyclin-dependent kinase 13

chr4_-_122521562 0.064 NM_198179
QRFPR
pyroglutamylated RFamide peptide receptor
chr19_-_5854718 0.063 NDUFA11
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
chr8_-_53789535 0.063 RB1CC1
RB1-inducible coiled-coil 1
chr9_+_35663852 0.063 NM_001216
CA9
carbonic anhydrase IX
chr6_+_31910623 0.063 NM_001040437
NM_001040438
C6orf48

chromosome 6 open reading frame 48

chr16_+_3447957 0.062 NM_001083600
NM_024845
NAT15

N-acetyltransferase 15 (GCN5-related, putative)

chr17_+_45008473 0.062 NXPH3
neurexophilin 3
chr19_+_11936868 0.061 NM_001012753
ZNF763
zinc finger protein 763
chr2_+_74595073 0.061 NM_016170
TLX2
T-cell leukemia homeobox 2
chr20_-_33463174 0.060 UQCC
ubiquinol-cytochrome c reductase complex chaperone
chr7_+_99451110 0.060 NM_003439
ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr15_-_73017439 0.057 NM_004255
COX5A
cytochrome c oxidase subunit Va
chr5_-_168204430 0.057


chr11_+_46595688 0.056 ATG13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr1_-_173979292 0.055 NM_003285
TNR
tenascin R (restrictin, janusin)
chr14_+_23654307 0.055 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr3_-_13032130 0.055


chr15_-_19974402 0.055


chr20_+_30192968 0.053 TM9SF4
transmembrane 9 superfamily protein member 4
chr16_+_27320983 0.053 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr19_+_44591589 0.053


chr1_-_44912649 0.052 NM_024587
TMEM53
transmembrane protein 53
chr16_+_31027231 0.052 BCKDK
branched chain ketoacid dehydrogenase kinase
chr5_-_63293301 0.052 NM_000524
HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr20_+_39199263 0.051 PLCG1
phospholipase C, gamma 1
chr19_+_60878238 0.049 NM_001130072
NM_013333
EPN1

epsin 1

chr12_+_112143599 0.049 NM_001143819
NM_017901
TPCN1

two pore segment channel 1

chr19_-_52679287 0.048 NM_007059
KPTN
kaptin (actin binding protein)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
9.18 9.40e-03 GO:0032313 regulation of Rab GTPase activity
9.18 9.40e-03 GO:0032483 regulation of Rab protein signal transduction
3.07 2.65e-02 GO:0051056 regulation of small GTPase mediated signal transduction

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
8.94 2.56e-03 GO:0005097 Rab GTPase activator activity